US 12,453,716 B2
Small molecule antagonist to PACAP receptor and uses thereof
Victor May, Essex, VT (US); Matthias Brewer, Williston, VT (US); and Jianing Li, South Burlington, VT (US)
Assigned to University of Vermont and State Agricultural College, Burlington, VT (US)
Appl. No. 17/429,843
Filed by University of Vermont and State Agricultural College, Burlington, VT (US)
PCT Filed Feb. 13, 2020, PCT No. PCT/US2020/018098
§ 371(c)(1), (2) Date Aug. 10, 2021,
PCT Pub. No. WO2020/168068, PCT Pub. Date Aug. 20, 2020.
Claims priority of provisional application 62/804,874, filed on Feb. 13, 2019.
Prior Publication US 2022/0125762 A1, Apr. 28, 2022
Int. Cl. A61K 31/4045 (2006.01); A61K 31/166 (2006.01); A61K 31/437 (2006.01); C07C 251/80 (2006.01); C07D 209/10 (2006.01); C07D 471/04 (2006.01)
CPC A61K 31/4045 (2013.01) [A61K 31/166 (2013.01); A61K 31/437 (2013.01); C07C 251/80 (2013.01); C07D 209/10 (2013.01); C07D 471/04 (2013.01)] 14 Claims
 
1. A compound of Formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein:
each R1 is fluorine;
R2 is halogen or —NO2;
X1 is C—H; and
X2 is C—H or N.