US 12,453,714 B2
Composition comprising an ester of alpha-tocopherol for reducing the risk of preterm birth
Giorgio Panin, Rovigo (IT)
Assigned to HULKA S.R.L., Rovigo (IT)
Appl. No. 18/562,492
Filed by HULKA S.R.L., Rovigo (IT)
PCT Filed May 16, 2022, PCT No. PCT/EP2022/063177
§ 371(c)(1), (2) Date Nov. 20, 2023,
PCT Pub. No. WO2022/248269, PCT Pub. Date Dec. 1, 2022.
Claims priority of application No. 102021000013898 (IT), filed on May 27, 2021.
Prior Publication US 2024/0261255 A1, Aug. 8, 2024
Int. Cl. A61K 31/355 (2006.01); A61K 9/00 (2006.01); A61K 47/12 (2006.01); A61K 47/44 (2017.01); A61P 15/06 (2006.01)
CPC A61K 31/355 (2013.01) [A61K 9/006 (2013.01); A61K 47/12 (2013.01); A61K 47/44 (2013.01); A61P 15/06 (2018.01)] 7 Claims
 
1. A method of reducing a risk of preterm birth and low birth weight of an infant, said method comprising
topically applying to the oral cavity of a pregnant woman a composition in spray form thereby reducing the risk of preterm birth and low birth weight of an infant, said composition consisting of
an ester of vitamin E with a carboxylic acid of formula R—COOH, in which R is an alkyl radical having 1 to 19 carbon atoms, or an alkenyl or alkynyl radical having 2 to 19 carbon; and
an oily vehicle, wherein said oily vehicle is caprylic/capric glyceride.