	US 12,453,704 B2
	Method for producing particles
Tadahiko Morinaga, Kanagawa (JP); and Tatsuru Moritani, Kanagawa (JP)
Assigned to Ricoh Company, Ltd., Tokyo (JP)
Appl. No. 17/906,326
Filed by Tadahiko Morinaga, Kanagawa (JP); and Tatsuru Moritani, Kanagawa (JP)
PCT Filed Mar. 11, 2021, PCT No. PCT/JP2021/009698 § 371(c)(1), (2) Date Sep. 14, 2022, PCT Pub. No. WO2021/187289, PCT Pub. Date Sep. 23, 2021.
Claims priority of application No. 2020-045858 (JP), filed on Mar. 16, 2020.
Prior Publication US 2023/0106801 A1, Apr. 6, 2023
Int. Cl. A61K 9/50 (2006.01); A61K 9/48 (2006.01); C07K 16/42 (2006.01)

CPC A61K 9/5031 (2013.01) [A61K 9/4858 (2013.01); A61K 9/5089 (2013.01); C07K 16/4241 (2013.01)]

4 Claims

1. A method for producing particles, the method comprising:

preparing a dispersion liquid with Liquid A and Liquid B, where Liquid A is a solution comprising a physiologically active substance, and Liquid B is a solution comprising a base material and a surfactant; and

forming particles from the dispersion liquid,

wherein the surfactant comprises sorbitan sesquioleate,

the base material comprises a biodegradable resin which comprises at least one resin selected from the group consisting of polylactic acid and a polylactic acid-glycolic acid copolymer,

the physiologically active substance is an antibody, and the particles are sustained-release particles.