US 12,453,703 B2
Humic substance-encapsulated particles, compositions and method of making the same
Oscar Urrutia Sagardia, Pamplona (ES); Javier Erro Garces, Pamplona (ES); Marta Fuentes Ramirez, Pamplona (ES); Roberto Baigorri Ekisoain, Huarte (ES); Angel Maria Zamarreno Arregui, Eugui (ES); Jean-Claude Yvin, Saint-Malo (FR); and Jose Maria Garcia-Mina Freire, Iza (ES)
Assigned to Agro Innovation International, Saint Malo (FR); and Universidad de Navarra, Pamplona (ES)
Appl. No. 16/486,125
Filed by Agro Innovation International, Saint Malo (FR); and Universidad de Navarra, Pamplona (ES)
PCT Filed Feb. 13, 2018, PCT No. PCT/EP2018/053558
§ 371(c)(1), (2) Date Aug. 14, 2019,
PCT Pub. No. WO2018/149825, PCT Pub. Date Aug. 23, 2018.
Claims priority of application No. ES201730174 (ES), filed on Feb. 14, 2017.
Prior Publication US 2020/0230065 A1, Jul. 23, 2020
Int. Cl. A61K 9/48 (2006.01); A01N 25/26 (2006.01); A23L 33/10 (2016.01)
CPC A61K 9/4816 (2013.01) [A01N 25/26 (2013.01); A23L 33/10 (2016.08); A61K 9/4833 (2013.01)] 28 Claims
 
1. A method for preparing a composition comprising a humic substance-encapsulated bioactive compound, said method comprising the steps of:
(a) preparing a solution comprising a humic substance and a bioactive compound, said solution having a pH greater than or equal to pH 4, and
(b) lowering the pH of the solution to a pH lower than 4,
(c) treating the solution obtained in step b) with ultrasound to form a gel, and
(d) mixing the gel in water.