US 12,453,702 B2
Apparatus and method for cryogranulating a pharmaceutical composition
Edwin Amoro, West Haven, CT (US); Karel Vanackere, Knokke-Heist (BE); and Michael A. White, Brookfield, CT (US)
Assigned to MannKind Corporation, Westlake Village, CA (US)
Filed by MannKind Corporation, Westlake Village, CA (US)
Filed on Nov. 2, 2023, as Appl. No. 18/500,199.
Application 16/675,471 is a division of application No. 16/051,645, filed on Aug. 1, 2018, granted, now 10,500,159, issued on Dec. 10, 2019.
Application 15/407,375 is a division of application No. 14/065,609, filed on Oct. 29, 2013, granted, now 9,566,243, issued on Feb. 14, 2017.
Application 18/500,199 is a continuation of application No. 17/363,162, filed on Jun. 30, 2021, granted, now 11,839,688.
Application 17/363,162 is a continuation of application No. 16/675,471, filed on Nov. 6, 2019, granted, now 11,077,063, issued on Aug. 3, 2021.
Application 16/051,645 is a continuation of application No. 15/407,375, filed on Jan. 17, 2017, granted, now 10,052,285, issued on Aug. 21, 2018.
Application 14/065,609 is a continuation of application No. 12/917,623, filed on Nov. 2, 2010, granted, now 8,590,320, issued on Nov. 26, 2013.
Claims priority of provisional application 61/257,385, filed on Nov. 2, 2009.
Prior Publication US 2024/0074976 A1, Mar. 7, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/16 (2006.01); A61J 3/00 (2006.01); A61K 38/28 (2006.01); B01J 2/06 (2006.01)
CPC A61K 9/1682 (2013.01) [A61J 3/00 (2013.01); A61K 9/16 (2013.01); A61K 9/1617 (2013.01); A61K 38/28 (2013.01); B01J 2/06 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A dispenser assembly for supplying a fluid into a cooling agent in a cryogranulation system, comprising:
a housing and a dispenser subassembly, the housing configured to mount the dispenser subassembly above the cooling agent, the dispenser subassembly including an enclosure defining an interior chamber, at least one inlet port coupled to the interior chamber and a plurality of dispenser ports, wherein the dispenser ports of the dispenser subassembly include first and second rows of dispenser ports, the first and second rows of dispenser ports being angled with respect to vertical, and wherein the dispenser ports of the first row are disposed at opposite angles with respect to the dispenser ports of the second row.