US 12,453,687 B2
Anti-DKK-1 antibody promoting growth of human dermal papilla cell and use thereof
Hee-Jun Na, Chuncheon-si (KR); Yun-Suk Lee, Chuncheon-si (KR); Je-Ok Yoo, Chuncheon-si (KR); Kwang-Soon Lee, Chuncheon-si (KR); and Ji Young Lee, Chuncheon-si (KR)
Assigned to HAUUL BIO, Chuncheon-si (KR)
Appl. No. 17/800,879
Filed by HAUUL BIO, Chuncheon-si (KR)
PCT Filed Sep. 27, 2021, PCT No. PCT/KR2021/013108
§ 371(c)(1), (2) Date Aug. 18, 2022,
PCT Pub. No. WO2022/108090, PCT Pub. Date May 27, 2022.
Claims priority of application No. 10-2020-0156652 (KR), filed on Nov. 20, 2020.
Prior Publication US 2023/0093472 A1, Mar. 23, 2023
Int. Cl. A61K 39/00 (2006.01); A61K 8/64 (2006.01); A61K 39/395 (2006.01); A61Q 7/00 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); C07K 16/46 (2006.01)
CPC A61K 8/64 (2013.01) [A61K 39/00 (2013.01); A61Q 7/00 (2013.01); C07K 16/18 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2319/10 (2013.01)] 8 Claims
 
1. An anti-DKK-1 antibody or antigen-binding fragment thereof specifically binding to Dickkopf-related protein 1 (DKK-1), comprising a light chain variable region comprising a light chain CDR1 comprising the amino acid sequence set forth SEQ ID NO: 1, a light chain CDR2 comprising the amino acid sequence set forth SEQ ID NO: 2, and a light chain CDR3 comprising the amino acid sequence set forth SEQ ID NO: 3; and a heavy chain variable region comprising a heavy chain CDR1 comprising the amino acid sequence set forth SEQ ID NO: 4, a heavy chain CDR2 comprising the amino acid sequence set forth SEQ ID NO: 5, and a heavy chain CDR3 comprising the amino acid sequence set forth SEQ ID NO: 6.