US 12,453,652 B2
Systems and methods treating for corneal ectatic disorders
Rajesh K. Rajpal, McLean, VA (US); and Grace Elizabeth Lytle, Boston, MA (US)
Assigned to Avedro, Inc., Burlington, MA (US)
Filed by Avedro, Inc., Waltham, MA (US)
Filed on Sep. 19, 2019, as Appl. No. 16/575,428.
Claims priority of provisional application 62/733,617, filed on Sep. 19, 2018.
Prior Publication US 2020/0085617 A1, Mar. 19, 2020
Int. Cl. A61F 9/008 (2006.01); A61F 9/00 (2006.01); A61N 5/06 (2006.01)
CPC A61F 9/0017 (2013.01) [A61N 5/062 (2013.01); A61F 2009/00872 (2013.01); A61F 2009/00893 (2013.01); A61N 2005/0661 (2013.01); A61N 2005/0662 (2013.01); A61N 2005/0665 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A system for treating an eye, comprising:
a light source configured to provide a photoactivating light that photoactivates a cross-linking agent applied to an eye, the light source further configured to pulse the photoactivating light at a pulse rate between approximately 1,000 Hz to 100,000 Hz;
an oxygen delivery device configured to provide a concentration of oxygen from an oxygen source to a cornea of the eye;
one or more optical elements configured to receive the photoactivating light and transmit the photoactivating light to the eye according to a pattern defined by a plurality of treatment zones; and
a controller including one or more processors configured to execute program instructions stored on a one or more computer-readable media, the program instructions causing the one or more processors to determine a location of the plurality of treatment zones and to control at least one of the light source and the one or more optical elements to deliver the pattern of photoactivating light according to the location of the plurality of treatment zones,
wherein the treatment zones are delivered to different respective areas on the eye, the plurality of treatment zones include at least a first treatment zone and a second treatment zone, the at least first treatment zone and the second treatment zone collectively encompassing an entire surface of the cornea of the eye, the first treatment zone configured to provide a first dose of the photoactivating light to a center of an ectatic cone for a first treatment time, the second treatment zone configured to provide a second dose of the photoactivating light offset from the center of the ectatic cone for a second treatment time, the first dose being less than the second dose, and the first treatment zone being disposed within an inner boundary of the second treatment zone, and
wherein the one or more processors control at least one of the light source and the one or more optical elements to deliver the first dose of the photoactivating light as the first treatment zone to the ectatic cone and to deliver the second dose of the photoactivating light as the second treatment zone to areas of the cornea outside the ectatic cone.