US 12,453,628 B2
Temporary synthetic carrier for corneal tissue insertion and tissue delivery
Christopher Sales, New York, NY (US); and David Putnam, New York, NY (US)
Assigned to Cornell University, Ithaca, NY (US)
Appl. No. 17/609,231
Filed by Cornell University, Ithaca, NY (US)
PCT Filed May 6, 2020, PCT No. PCT/US2020/031673
§ 371(c)(1), (2) Date Nov. 5, 2021,
PCT Pub. No. WO2020/227407, PCT Pub. Date Nov. 12, 2020.
Claims priority of provisional application 62/876,390, filed on Jul. 19, 2019.
Claims priority of provisional application 62/844,710, filed on May 7, 2019.
Prior Publication US 2022/0354633 A1, Nov. 10, 2022
Int. Cl. A61F 2/14 (2006.01); A61L 27/18 (2006.01); A61L 27/20 (2006.01); A61L 27/26 (2006.01); A61L 27/36 (2006.01); A61L 27/58 (2006.01)
CPC A61F 2/142 (2013.01) [A61L 27/18 (2013.01); A61L 27/20 (2013.01); A61L 27/26 (2013.01); A61L 27/3604 (2013.01); A61L 27/3666 (2013.01); A61L 27/58 (2013.01); A61F 2210/0076 (2013.01); A61F 2250/0031 (2013.01); A61F 2250/0059 (2013.01); A61L 2430/16 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An endothelial keratoplasty device comprising:
a Descemet membrane endothelial tissue layer; and
a synthetic scaffold adhered to the Descemet membrane endothelial tissue layer to reduce spontaneous scrolling of the Descemet membrane endothelial tissue layer in an aqueous environment;
wherein the synthetic scaffold comprises at least two layers, wherein the synthetic scaffold comprises a first layer comprising at least 50% carboxymethylcellulose (CMC), polyethylene glycol (PEG), and/or hyaluronic acid (HA), and a second layer comprising at least 50% HA.