US 12,453,509 B2
Optical coherence tomography based sperm detection method and devices and systems for performing the same
Yanhe Lue, Torrance, CA (US); Boris Hyle Park, Torrance, CA (US); Ronald Swerdloff, Torrance, CA (US); Jacob Rajfer, Torrance, CA (US); Christina Wang, Torrance, CA (US); and Junze Liu, Torrance, CA (US)
Assigned to Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (US); and The Regents of the University of California, Oakland, CA (US)
Filed by Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (US); and The Regents of the University of California, Oakland, CA (US)
Filed on Feb. 24, 2022, as Appl. No. 17/679,516.
Application 17/679,516 is a continuation of application No. PCT/US2020/048247, filed on Aug. 27, 2020.
Claims priority of provisional application 62/893,174, filed on Aug. 28, 2019.
Prior Publication US 2022/0370004 A1, Nov. 24, 2022
Int. Cl. A61B 5/00 (2006.01); A61B 10/00 (2006.01); A61B 17/43 (2006.01)
CPC A61B 5/4387 (2013.01) [A61B 5/0066 (2013.01); A61B 10/0058 (2013.01); A61B 17/43 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of identifying sperm in testicular tissue, the method comprising:
volumetrically imaging testicular tissue by optical coherence tomography to identify one or more tubule locations that are likely to contain sperm; and
M-mode scanning the identified testicular location using optical coherence tomography to determine whether sperm are at least likely to be present at the tubule location,
wherein the M-mode scanning is employed to identify phase variance at the tubule locations that are likely to contain sperm.