US 12,453,505 B2
Intraprocedural automated system for localizing idiopathic ventricular arrhythmia origins
Natalia Trayanova, Baltimore, MD (US); Shijie A. Zhou, Baltimore, MD (US); Jonathan Chrispin, Baltimore, MD (US); John Sapp, Halifax (CA); and Amir Abdelwahab, Halifax (CA)
Assigned to THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US)
Appl. No. 18/041,506
Filed by THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US)
PCT Filed Aug. 5, 2021, PCT No. PCT/US2021/044684
§ 371(c)(1), (2) Date Feb. 13, 2023,
PCT Pub. No. WO2022/039938, PCT Pub. Date Feb. 24, 2022.
Claims priority of provisional application 63/068,099, filed on Aug. 20, 2020.
Prior Publication US 2023/0363689 A1, Nov. 16, 2023
Int. Cl. A61B 5/367 (2021.01); A61B 5/366 (2021.01); A61B 18/00 (2006.01)
CPC A61B 5/367 (2021.01) [A61B 5/366 (2021.01); A61B 2018/00351 (2013.01); A61B 2018/00577 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An intraprocedural method of identifying a location of an origin of an idiopathic ventricular arrhythmia in a patient, the method comprising:
acquiring an at least partial electroanatomical geometry of the patient;
acquiring an electrocardiogram segment of the idiopathic ventricular arrhythmia of the patient;
calculating at least one integral of the electrocardiogram segment of the idiopathic ventricular arrhythmia;
acquiring a plurality of pacing site sets of coordinates obtained by an intracardiac instrument for the patient;
acquiring a plurality of pacing electrocardiogram segments of the patient, each pacing site set of coordinates of the plurality of pacing site sets of coordinates corresponding to at least one pacing electrocardiogram segment of the plurality of pacing electrocardiogram segments;
calculating at least one pacing integral for each of the pacing electrocardiogram segments of the plurality of pacing electrocardiogram segments, whereby each pacing site set of coordinates of the plurality of pacing site of sets coordinates corresponds to at least one pacing integral;
relating each pacing site set of coordinates of the plurality of pacing site sets of coordinates to at least one corresponding pacing integral, whereby a plurality of patient-specific regression coefficients are obtained, wherein the patient-specific regression coefficients link pacing site location coordinates to electrocardiogram integrals;
determining an estimated set of coordinates of the origin of the idiopathic ventricular arrhythmia based on at least one integral of the electrocardiogram segment of the idiopathic ventricular arrhythmia of the patient and on the plurality of patient-specific regression coefficients; and
projecting the estimated set of coordinates of the origin of the idiopathic ventricular arrhythmia on to the at least partial electroanatomical geometry of the patient, whereby a map of a location of the origin of the idiopathic ventricular arrhythmia is obtained.