	US 12,453,500 B2
	Poroelastic materials, biosensors comprising poroelastic materials, and methods of making and using poroelastic materials and biosensors
Craig J. Goergen, West Lafayette, IN (US); Chi Hwan Lee, West Lafayette, IN (US); Bongjoong Kim, Seoul (KR); and Kwan-Soo Lee, Los Alamos, NM (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US); and Triad National Security, LLC, Los Alamos, NM (US)
Filed by Purdue Research Foundation, West Lafayette, IN (US); and Triad National Security, LLC, Los Alamos, NM (US)
Filed on May 11, 2022, as Appl. No. 17/742,186.
Claims priority of provisional application 63/186,942, filed on May 11, 2021.
Prior Publication US 2022/0363860 A1, Nov. 17, 2022
Int. Cl. A61B 5/268 (2021.01); A61B 5/263 (2021.01); C08G 77/06 (2006.01); C08G 77/12 (2006.01); C08J 3/24 (2006.01); C08J 9/12 (2006.01); C08J 9/40 (2006.01); C08K 3/08 (2006.01); C08G 77/00 (2006.01)

CPC A61B 5/263 (2021.01) [A61B 5/268 (2021.01); C08G 77/06 (2013.01); C08G 77/12 (2013.01); C08J 3/242 (2013.01); C08J 9/125 (2013.01); C08J 9/40 (2013.01); C08K 3/08 (2013.01); A61B 2562/12 (2013.01); A61B 2562/164 (2013.01); C08G 77/80 (2013.01); C08J 2203/10 (2013.01); C08J 2205/044 (2013.01); C08J 2207/10 (2013.01); C08J 2383/05 (2013.01); C08K 2003/0806 (2013.01); C08K 2201/001 (2013.01); C08K 2201/011 (2013.01)]

20 Claims

6. A biosensor comprising:

a first layer formed of a poroelastic material comprising a porous medium having a solid matrix formed of a polymer material and electrically conductive nanomaterials in and/or connected through pores of the porous medium;

a second layer formed of metallic material located on a first surface of the first layer, the second layer forming interconnections with the electrically conductive nanomaterials of the poroelastic material in the first layer;

a third layer formed of a biocompatible metallic material located on and covering the second layer; and

a fourth layer formed of a polymer insulator material located on a second surface of the first layer.