US 12,453,496 B2
Silicon carbide nanoparticles fibrous membrane for implantable glucose sensor integrated with chronoamperometric potentiostat
Kavyashree Puttananjegowda, Tampa, FL (US); Sylvia Thomas, Orlando, FL (US); and Arash Takshi, Tampa, FL (US)
Assigned to UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US)
Filed by University of South Florida, Tampa, FL (US)
Filed on Jun. 1, 2021, as Appl. No. 17/335,276.
Claims priority of provisional application 63/033,257, filed on Jun. 2, 2020.
Prior Publication US 2021/0369157 A1, Dec. 2, 2021
Int. Cl. A61B 5/1486 (2006.01); A61B 5/145 (2006.01)
CPC A61B 5/14865 (2013.01) [A61B 5/14532 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A glucose monitoring system comprising:
a glucose monitoring sensor having at least a counter electrode, a reference electrode, and a working electrode;
a silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane contacting the working electrode;
a glucose oxidase enzyme solution in direct contact with the silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane, wherein a conductive polymer membrane assists in binding the glucose oxidase enzyme composition with the silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane, and
wherein the glucose monitoring sensor further comprises a potentiostat connected to detect a current having an amperage ranging from 2 μA to 200 μA from the working electrode, wherein the amperage is electrochemically determined within such range based on a degree of presence of glucose in contact with at least one of: the glucose oxidase enzyme solution, the conductive polymer membrane, and the silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane.