US 12,453,480 B2
Systems and methods for assessing and treating hemorrhage and other conditions
Gregory Kermit Peterson, Centerville, MN (US); Elizabeth Rose Lusczek, St. Paul, MN (US); Gregory Joseph Beilman, Richfield, MN (US); Kristine Elizabeth Mulier, Vadnais Heights, MN (US); and Philippe Pierre Joseph Buhlmann, Minneapolis, MN (US)
Assigned to REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
Filed by REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
Filed on Apr. 28, 2020, as Appl. No. 16/860,529.
Claims priority of provisional application 62/840,207, filed on Apr. 29, 2019.
Prior Publication US 2020/0337566 A1, Oct. 29, 2020
Int. Cl. A61B 5/0205 (2006.01); A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/021 (2006.01); A61B 5/024 (2006.01); A61B 5/08 (2006.01); A61B 5/145 (2006.01); A61B 5/20 (2006.01); G01N 33/497 (2006.01); G01N 33/50 (2006.01)
CPC A61B 5/02042 (2013.01) [A61B 5/0205 (2013.01); A61B 5/082 (2013.01); A61B 5/14546 (2013.01); A61B 5/208 (2013.01); A61B 5/7264 (2013.01); G01N 33/497 (2013.01); G01N 33/50 (2013.01); A61B 5/021 (2013.01); A61B 5/024 (2013.01); A61B 5/0816 (2013.01); G01N 33/4975 (2024.05)] 17 Claims
OG exemplary drawing
 
1. A method for detecting hemorrhage in a subject, comprising:
obtaining a breath sample from the subject;
contacting the breath sample with a reactant, wherein the reactant reacts with succinate in the breath sample to form a reaction product, wherein the reaction product exhibits a higher vapor pressure at a given temperature than succinate;
contacting the reaction product with a chemical sensor element, the chemical sensor element comprising a plurality of discrete graphene varactors;
sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set; and
classifying the sample data set into one or more preestablished hemorrhage classifications based on succinate concentrations.