US 12,453,348 B2
Antimicrobial with modified-chitosan functionalization via dopamine linkage
Randell Clevenger, North Plainfield, NJ (US); Cheoljin Kim, North Brunswick, NJ (US); and Kristin Blacklock, Holmdel, NJ (US)
Assigned to Quatssant, LLC, Monmouth Junction, NJ (US)
Filed by Quatssant, LLC, Monmouth Junction, NJ (US)
Filed on Jul. 20, 2022, as Appl. No. 17/869,064.
Claims priority of provisional application 63/223,969, filed on Jul. 20, 2021.
Prior Publication US 2023/0025164 A1, Jan. 26, 2023
Int. Cl. A01N 43/16 (2006.01); A01N 57/34 (2006.01); C08B 37/08 (2006.01)
CPC A01N 43/16 (2013.01) [A01N 57/34 (2013.01); C08B 37/003 (2013.01)] 16 Claims
 
1. A composition comprising a substrate and a chitosan polymer or oligomer having a general formula

OG Complex Work Unit Chemistry
wherein
n ranges from 1 to about 300;
each of R1, R2, R3 is independently selected from a thiol, an alkane, an alkene, an alkyne, a secondary amine, a nitrile, an aldehyde, an imidazole, an azide, a halide, a polyhexamethylene dithiocarbonate, a hydrogen, a hydroxyl, a carboxylic acid, an aldehyde, a carboxylic ester, a carboxamide, a urea, a catechol, a quaternary ammonium, a quaternary phosphonium, a quaternary pyridinium, or combinations thereof;
at least one of the R1, R2, and R3 groups in the polymer or oligomer comprises the quaternary ammonium, the quaternary phosphonium, or the quaternary pyridinium;
the chitosan polymer or oligomer has between about 1 to about 99% quaternization; and
at least one of the R1 groups in the polymer or oligomer is a substituted or unsubstituted dopamine or a derivative thereof, wherein the dopamine or derivative thereof is bound to the substrate, and wherein the dopamine or derivative thereof is bound to the chitosan polymer or oligomer via a —NH—C(O)— group which forms a —NH—C(O)—NH— group in combination with the —NH— group that is bound between R1 and the chitosan pyranose ring.