US 12,123,857 B2
Techniques for checking state of analyzers
Marc Kaminski, Penzberg (DE); Stefan Quint, Munich (DE); and Benjamin Tiemann, Munich (DE)
Assigned to Roche Diagnostics Operations, Inc., Indianapolis, IN (US)
Filed by Roche Diagnostics Operations, Inc., Indianapolis, IN (US)
Filed on Aug. 18, 2020, as Appl. No. 16/996,225.
Claims priority of application No. 19193864 (EP), filed on Aug. 27, 2019.
Prior Publication US 2021/0063363 A1, Mar. 4, 2021
Int. Cl. G01N 30/72 (2006.01); G01N 30/20 (2006.01); G01N 30/88 (2006.01); G06F 16/28 (2019.01); G01N 30/02 (2006.01)
CPC G01N 30/88 (2013.01) [G01N 30/20 (2013.01); G06F 16/285 (2019.01); G01N 2030/027 (2013.01); G01N 2030/202 (2013.01); G01N 2030/8804 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of monitoring a state of a liquid chromatography (LC) stream of an automated analyzer, the method comprising:
executing, by at least one processor of a computer system configured to monitor the state of the LC stream of the automated analyzer, instructions stored in at least one memory of the computer system that cause the at least one processor to automatically:
inject, using a pump during an injection process, a sample of biological material into an LC column of the LC stream of the automated analyzer;
monitor a system pressure of an injection assembly of the LC stream during the injection process of the sample of biological material into the LC column of the LC stream to generate a time series of system pressures, wherein the time series of system pressures spans at least a portion of the injection process of the sample of biological material into the LC column of the LC stream;
classify the time series in one of two or more predetermined classes indicating different states of the LC stream; and
trigger a response based on the classification result,
wherein to classify the time series in the one of two or more predetermined classes comprises to classify the time series based on the following predetermined classes: (i) a first class indicative of a partial injection of air into the LC stream; (ii) a second class indicative of a complete injection of air into the LC stream; and (iii) a third class indicative of an injection of an abnormal sample composition into the LC stream.