	US 12,123,057 B2
	Methods for detecting an aneurysm
Ioannis Toumpoulis, Kato Achaia (GR); and Stavros Toumpoulis, Kato Achaia (GR)
Assigned to TWOBULL MEDITHERAPY P.C., Patra (GR)
Filed by TWOBULL MEDITHERAPY P.C., Patra (GR)
Filed on Nov. 17, 2020, as Appl. No. 16/950,825.
Application 16/950,825 is a continuation of application No. PCT/EP2018/062897, filed on May 17, 2018.
Prior Publication US 2021/0102258 A1, Apr. 8, 2021
Int. Cl. C12Q 1/6883 (2018.01); C12Q 1/6886 (2018.01)

CPC C12Q 1/6883 (2013.01) [C12Q 1/6886 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01)]

3 Claims

1. A method of treating an aneurysm in a human subject, the method comprising:

(i) determining that the human subject suffers from an aneurysm by determining that the level of mRNA of each one of COL11A1, COL5A2, COL5A1, TGFB1, ITGA4, ITGB1, MMP2, MMP9 and BMP1 genes in a peripheral blood sample from the subject are higher than a reference value; and

(ii) subsequently treating the human subject with a therapeutic regime selected from the group consisting of open surgery to avoid the rupture of the blood vessel, endovascular repair with stent graft implantation, administration of a statin, administration of a beta-blocker, administration of an anti-hypertensive agent, and a combination thereof.