US 12,122,859 B2
Hydrophilic polymeric particles and methods for making and using same
Geir Fonnum, Oslo (NO); Grete Irene Modahl, Oslo (NO); Nini Hofsloekken Kjus, Oslo (NO); Astrid Evenroed Molteberg, Fetsund (NO); Diem Thuy Thi Tran, Lillestroem (NO); Jo Aaserud, Skjetten (NO); M. Talha Gokmen, Fjellhamar (NO); Steven M. Menchen, Fremont, CA (US); Carl Fuller, Berkeley Heights, NJ (US); Luisa Andruzzi, Beverly, MA (US); and Wolfgang Hinz, Killingworth, CT (US)
Assigned to Life Technologies AS, Oslo (NO); and Life Technologies Corporation, Carlsbad, CA (US)
Filed by LIFE TECHNOLOGIES CORPORATION, Carlsbad, CA (US); and LIFE TECHNOLOGIES AS, Oslo (NO)
Filed on Jan. 26, 2023, as Appl. No. 18/101,785.
Application 18/101,785 is a continuation of application No. 17/165,039, filed on Feb. 2, 2021, granted, now 11,572,427.
Application 17/165,039 is a continuation of application No. 16/259,963, filed on Jan. 28, 2019, granted, now 10,947,333, issued on Mar. 16, 2021.
Application 16/259,963 is a continuation of application No. 15/005,420, filed on Jan. 25, 2016, granted, now 10,202,473, issued on Feb. 12, 2019.
Application 15/005,420 is a continuation of application No. 13/762,941, filed on Feb. 8, 2013, granted, now 9,243,085, issued on Jan. 26, 2016.
Claims priority of provisional application 61/731,873, filed on Nov. 30, 2012.
Claims priority of provisional application 61/719,045, filed on Oct. 26, 2012.
Claims priority of provisional application 61/597,053, filed on Feb. 9, 2012.
Prior Publication US 2023/0167210 A1, Jun. 1, 2023
Int. Cl. C08F 230/08 (2006.01); C07F 7/18 (2006.01); C08F 2/20 (2006.01); C08F 2/26 (2006.01); C08F 6/24 (2006.01); C08F 8/12 (2006.01); C08F 8/32 (2006.01); C08F 8/34 (2006.01); C08F 130/08 (2006.01); C08F 220/58 (2006.01); C08F 222/38 (2006.01); C08J 9/20 (2006.01); C12P 19/34 (2006.01); C12Q 1/686 (2018.01); C12Q 1/6874 (2018.01); G01N 27/414 (2006.01); C08F 220/60 (2006.01)
CPC C08F 130/08 (2013.01) [C07F 7/1804 (2013.01); C07F 7/188 (2013.01); C08F 2/20 (2013.01); C08F 2/26 (2013.01); C08F 6/24 (2013.01); C08F 8/12 (2013.01); C08F 8/32 (2013.01); C08F 8/34 (2013.01); C08F 222/385 (2013.01); C08F 230/085 (2020.02); C08J 9/20 (2013.01); C12P 19/34 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6874 (2013.01); G01N 27/4145 (2013.01); C08F 220/603 (2020.02); C08F 2800/20 (2013.01); C08J 2343/04 (2013.01); Y10T 428/2982 (2015.01)] 20 Claims
 
1. A method of forming a particle, the method comprising:
promoting a seed particle in an aqueous suspension to form a disperse phase within the aqueous suspension, wherein the seed particle has an initial particle size in a range of at least 0.17 micrometers and not greater than 0.6 micrometers;
adding a hydrophilic monomer having a hydrophobic protection group to the disperse phase;
in the disperse phase, polymerizing a plurality of mer units of the hydrophilic monomer, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups; and
converting the polymeric particle to a hydrogel particle.