CPC C07K 16/2866 (2013.01) [A61K 39/39558 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/734 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01)] | 9 Claims |
1. A method for treating hepatic fibrosis, renal fibrosis, pulmonary fibrosis, skin fibrosis, cardiovascular fibrosis and/or gastrointestinal fibrosis, comprising administering a humanized anti- C-C chemokine receptor type 7 (anti-CCR7) antibody comprising the hypervariable regions HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 and HVR-L3, wherein:
HVR-H1 comprises SEQ ID NO: 6;
HVR-H2 H1 comprises SEQ ID NO: 13;
HVR-H3 H1 comprises SEQ ID NO: 19;
HVR-L1 H1 comprises SEQ ID NO: 27;
HVR-L2 H1 comprises SEQ ID NO: 31; and
HVR-L3 H1 comprises SEQ ID NO: 36,
and wherein the antibody has at least one of:
a) a minimal affinity for a synthetic antigen with the amino acid sequence of SEQ ID NO: 76, wherein the minimal affinity is defined by a Kd that is not more than a 10× higher than the Kd of a mouse anti-CCR7 antibody of which the amino acid sequence of the heavy chain variable domain is SEQ ID NO: 1 and of which the amino acid sequence of the light chain variable domain is SEQ ID NO: 2; and,
b) an IC50 of no more than 100 nM for inhibiting CCR7-dependent intracellular signalling and/or CCR7 receptor internalization, by at least one CCR7-ligand selected from CCL19 and CCL21.
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