US 12,122,751 B2
Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
Xiangdong Jiao, Toronto (CA); and Kanjai Khumtaveeporn, Toronto (CA)
Assigned to Translatum Medicus Inc., Toronto (CA)
Filed by Translatum Medicus Inc., Toronto (CA)
Filed on Jul. 21, 2023, as Appl. No. 18/356,977.
Application 18/356,977 is a continuation of application No. 17/621,827, granted, now 11,753,382, previously published as PCT/IB2020/055994, filed on Jun. 24, 2020.
Claims priority of provisional application 62/866,321, filed on Jun. 25, 2019.
Prior Publication US 2024/0025859 A1, Jan. 25, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 231/56 (2006.01)
CPC C07D 231/56 (2013.01) 9 Claims
 
1. A process of making the compound of Formula (XVI)

OG Complex Work Unit Chemistry
the process comprising: reacting the compound of Formula (XVII)

OG Complex Work Unit Chemistry
in the presence of (R16)4NZ with the compound of Formula (VI)

OG Complex Work Unit Chemistry
to form the compound of Formula (XVI);
wherein R18, R19, R20 each is independently H or an alkyl group having from 1 to 6 carbon atoms,
R16 is an alkyl group having from 1 to 5 carbon atoms,
X is a leaving group,
Z is I, Br, or Cl.