US 12,121,896 B2
Nucleic acid sequencing by synthesis using magnetic sensor arrays
Yann Astier, Pleasanton, CA (US); Patrick Braganca, San Jose, CA (US); and Juraj Topolancik, Redwood City, CA (US)
Assigned to Roche Sequencing Solutions, Inc., Pleasanton, CA (US); and Sandisk Technologies, Inc., Milpitas, CA (US)
Appl. No. 17/602,319
Filed by Roche Sequencing Solutions, Inc., Pleasanton, CA (US); and Western Digital Technologies, Inc., San Jose, CA (US)
PCT Filed Apr. 8, 2020, PCT No. PCT/US2020/027290
§ 371(c)(1), (2) Date Oct. 8, 2021,
PCT Pub. No. WO2020/210370, PCT Pub. Date Oct. 15, 2020.
Claims priority of provisional application 62/833,130, filed on Apr. 12, 2019.
Prior Publication US 2022/0193670 A1, Jun. 23, 2022
Int. Cl. B01L 3/00 (2006.01); G01N 27/08 (2006.01); G01N 27/74 (2006.01); G01N 33/58 (2006.01); C12Q 1/6869 (2018.01)
CPC B01L 3/502715 (2013.01) [G01N 27/08 (2013.01); G01N 27/74 (2013.01); G01N 33/58 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/0896 (2013.01); B01L 2300/12 (2013.01); C12Q 1/6869 (2013.01)] 23 Claims
OG exemplary drawing
 
1. An apparatus, comprising:
a magnetic sensor array comprising:
a plurality of magnetic sensors, each of the plurality of magnetic sensors coupled to at least one address line, and
at least one selector element;
a fluid chamber adjacent to the magnetic sensor array, the fluid chamber comprising a proximal wall adjacent to the magnetic sensor array; and
sensing circuitry coupled to the magnetic sensor array via the at least one address line, wherein the sensing circuitry is configured to apply a current to the at least one address line to detect a characteristic of at least one of the plurality of magnetic sensors, wherein the characteristic indicates a presence or an absence of a magnetic label in the fluid chamber.