US 12,121,828 B2
Systems and methods of isolation of gallium-68
Joel Oscar Olsson Kumlin, Qualicum Beach (CA); Sogol Borjian Borojeni, Vancouver (CA); and Daniel Alexander Childs, Maple Ridge (CA)
Assigned to Telix ARTMS Inc., Ontario (CA)
Appl. No. 17/767,039
Filed by Telix ARTMS Inc., Toronto (CA)
PCT Filed Oct. 12, 2020, PCT No. PCT/IB2020/059581
§ 371(c)(1), (2) Date Apr. 6, 2022,
PCT Pub. No. WO2021/070164, PCT Pub. Date Apr. 15, 2021.
Claims priority of provisional application 62/914,476, filed on Oct. 12, 2019.
Prior Publication US 2022/0351873 A1, Nov. 3, 2022
Int. Cl. A61K 51/00 (2006.01); A61M 36/14 (2006.01); B01D 15/18 (2006.01); B01D 15/26 (2006.01); B01D 15/42 (2006.01); G21G 1/10 (2006.01); G21G 1/00 (2006.01)
CPC B01D 15/1871 (2013.01) [B01D 15/265 (2013.01); B01D 15/426 (2013.01); G21G 1/10 (2013.01); G21G 2001/0021 (2013.01)] 21 Claims
 
1. A process for preparation of a carrier-free Ga-68 solution from a solid target assembly, the process comprising:
adsorbing an irradiation target solution to a first chromatography column comprising a first chromatographic resin;
washing the first chromatography column with a first chromatography wash solution;
eluting a first eluate solution from the first chromatography column with a first chromatography column elution solution;
adsorbing the first eluate solution to a second chromatography column comprising a second chromatography resin;
collecting a second chromatography column flow-through solution from the second chromatography column;
adsorbing the second chromatography column flow-through solution to a third chromatography column comprising a third chromatography resin; and
eluting the carrier-free Ga-68 solution from the third chromatography column with a third chromatography column elution solution;
wherein the irradiation target solution comprises a solution formed by dissolution of at least a portion of an irradiation target portion of a solid target assembly;
wherein the irradiation target solution comprises Zn-68, Ga-68, and solid target assembly metals;
wherein the solid target assembly comprises a metal disc comprising front and rear surfaces, and the irradiation target portion disposed on the top surface of the disc;
wherein the irradiation target portion comprises a mixture of Zn-68 and Ga-68;
wherein the first chromatography resin comprises a hydroxamate chromatography resin;
wherein the first chromatography column wash solution has a strong acid present at a concentration of greater than about 4.5 M;
wherein the first chromatography column elution solution has a strong acid present at a concentration of less than about 3.5 M;
wherein the second chromatography resin comprises an alkyl orthophosphoric acid chromatography resin;
wherein the third chromatography resin comprises an alkyl phosphine oxide resin chromatography resin; and
wherein the third chromatography column elution solution optionally comprises a strong acid present at a concentration less than about 0.2 M.