US 12,121,560 B2
Methods and compositions for maintaining the conformation and structural integrity of biomolecules
Paul R. Sood, Dallas, TX (US); Alpeshkumar P. Patel, Sachse, TX (US); Jennifer Seifert, Little Elm, TX (US); and Ryszard Zarzycki, Dallas, TX (US)
Assigned to TissueGen, Inc., Irving, TX (US)
Filed by TissueGen, Inc., Dallas, TX (US)
Filed on Nov. 9, 2021, as Appl. No. 17/522,570.
Application 17/522,570 is a continuation of application No. 16/521,297, filed on Jul. 24, 2019, granted, now 11,197,905.
Application 16/521,297 is a continuation of application No. 15/653,414, filed on Jul. 18, 2017, granted, now 10,363,281, issued on Jul. 30, 2019.
Claims priority of provisional application 62/363,593, filed on Jul. 18, 2016.
Prior Publication US 2022/0062370 A1, Mar. 3, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/00 (2006.01); C08B 37/00 (2006.01); C08B 37/02 (2006.01); C08H 1/00 (2006.01); C08H 1/06 (2006.01); C08L 3/02 (2006.01); C08L 5/00 (2006.01); C08L 5/02 (2006.01); C08L 5/04 (2006.01); C08L 5/08 (2006.01); C08L 5/12 (2006.01); C08L 89/00 (2006.01); C08L 89/06 (2006.01)
CPC A61K 38/00 (2013.01) [C08B 37/0006 (2013.01); C08B 37/0021 (2013.01); C08B 37/0084 (2013.01); C08H 1/00 (2013.01); C08H 1/06 (2013.01); C08L 3/02 (2013.01); C08L 5/00 (2013.01); C08L 5/02 (2013.01); C08L 5/04 (2013.01); C08L 5/08 (2013.01); C08L 5/12 (2013.01); C08L 89/00 (2013.01); C08L 89/06 (2013.01)] 3 Claims
 
1. A liquid ink composition configured for three-dimensional printing comprising:
a liquid phase comprising a polymer, and
particles, poorly swellable in the liquid phase, suspended in the liquid phase, the particles containing an active pharmaceutical or biological agent in a native configuration with preserved biological activity
wherein the liquid phase is configured to solidify to form a three dimensional structure, and
wherein the biological activity of the pharmaceutical or biological agent is preserved upon solidification of the liquid phase.