US 12,121,475 B2
Localized cooling to induce browning of adipose tissue
Dieter Manstein, Coral Gables, FL (US); Michael Evers, Cambridge, MA (US); and Nunciada Salma, Bolton, MA (US)
Assigned to THE GENERAL HOSPITAL CORPORATION, Boston, MA (US)
Appl. No. 17/430,761
Filed by THE GENERAL HOSPITAL CORPORATION, Boston, MA (US)
PCT Filed Feb. 13, 2020, PCT No. PCT/US2020/018182
§ 371(c)(1), (2) Date Aug. 13, 2021,
PCT Pub. No. WO2020/168124, PCT Pub. Date Aug. 20, 2020.
Claims priority of provisional application 62/804,867, filed on Feb. 13, 2019.
Prior Publication US 2022/0133531 A1, May 5, 2022
Int. Cl. A61F 7/12 (2006.01); A61F 7/00 (2006.01); A61F 7/02 (2006.01)
CPC A61F 7/12 (2013.01) [A61F 2007/0009 (2013.01); A61F 2007/0022 (2013.01); A61F 2007/0023 (2013.01); A61F 2007/004 (2013.01); A61F 2007/0075 (2013.01); A61F 2007/029 (2013.01); A61F 2007/126 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A method of inducing remote browning of adipose tissue in a subject comprising carrying out a plurality of treatments on the subject wherein the treatments comprise at least a first treatment and a second treatment, wherein the first treatment comprises cooling a first local adipose tissue deposit to a temperature of between 0° C. to 30° C. for a first period of time sufficient to induce browning of adipose tissue in one or more areas of the subject's body remote to the first local adipose tissue deposit;
and wherein the second treatment comprises cooling a second local adipose tissue deposit to a temperature of 0° C. to 30° C. for a second period of time sufficient to induce browning of adipose tissue in one or more areas of the subject's body remote to the second local adipose tissue deposit;
wherein the first and second local adipose tissue deposits are the same or are different; and
wherein the second treatment is carried out 2-30 days after the day that the first treatment is carried out.