US 12,121,251 B1
Computer-aided vacuum thrombectomy systems and methods for estimating therapeutic benefit
Nicole Trosper, Fairfax, CA (US); and Stephen Pons, Alameda, CA (US)
Assigned to Penumbra, Inc., Alameda, CA (US)
Filed by Penumbra, Inc., Alameda, CA (US)
Filed on Jun. 21, 2024, as Appl. No. 18/750,634.
Application 18/750,634 is a continuation in part of application No. 18/492,674, filed on Oct. 23, 2023.
Application 18/750,634 is a continuation in part of application No. 18/469,445, filed on Sep. 18, 2023.
Application 18/492,674 is a continuation of application No. 17/463,939, filed on Sep. 1, 2021, granted, now 11,793,542, issued on Oct. 24, 2023.
Application 18/469,445 is a continuation of application No. 16/977,431, granted, now 11,759,218, issued on Sep. 19, 2023, previously published as PCT/US2019/043095, filed on Jul. 23, 2019.
Claims priority of provisional application 62/778,708, filed on Dec. 12, 2018.
Claims priority of provisional application 62/702,804, filed on Jul. 24, 2018.
Int. Cl. A61B 17/3207 (2006.01); A61B 17/22 (2006.01); A61M 1/00 (2006.01); A61B 17/00 (2006.01); A61B 17/3203 (2006.01); A61B 17/34 (2006.01); A61B 90/00 (2016.01); A61M 39/10 (2006.01)
CPC A61B 17/22 (2013.01) [A61M 1/75 (2021.05); A61M 1/76 (2021.05); A61M 1/77 (2021.05); A61M 1/774 (2021.05); A61B 17/00 (2013.01); A61B 2017/00022 (2013.01); A61B 2017/00561 (2013.01); A61B 17/32037 (2013.01); A61B 17/3498 (2013.01); A61B 90/06 (2016.02); A61B 2090/064 (2016.02); A61B 2217/005 (2013.01); A61M 39/105 (2013.01); A61M 2205/3334 (2013.01); A61M 2205/3344 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An aspiration thrombectomy system, comprising:
an aspiration catheter having a proximal end and a distal end, wherein the aspiration catheter is configured to accommodate fluid, and wherein the distal end is configured to interface with occlusive material in a vasculature of a patient;
connection tubing coupled to the aspiration catheter, wherein the connection tubing is configured to act as a common conduit for fluid communication between the aspiration catheter and a vacuum source;
one or more controllable valves, wherein each valve is operable to selectively open and close to control a level of pressure in the aspiration catheter;
one or more pressure sensors, wherein each pressure sensor is positioned proximally downstream from the distal end of the aspiration catheter within the aspiration thrombectomy system; and
a controller configured to, during operation of the aspiration thrombectomy system for an aspiration thrombectomy procedure:
detect, via one or more of the pressure sensors, a set of pressure levels associated with one or more positions associated with one or more of the pressure sensors, the aspiration catheter, or the connection tubing;
determine, based on the set of pressure levels, a vascular pressure level associated with one or more positions in the vasculature of the patient, wherein the vascular pressure level is a first endpoint determinant of a plurality of endpoint determinants;
calculate, at one or more points in time during the aspiration thrombectomy procedure, based on the first endpoint determinant and one or more second endpoint determinants, one or more therapeutic-benefit metrics associated with a continuance of the aspiration thrombectomy procedure;
determine, for the one or more points in time, based on the first endpoint determinant and one or more of the second endpoint determinants, whether one or more of the therapeutic-benefit metrics exceeds one or more confidence metrics associated with the continuance of the aspiration thrombectomy procedure; and
transmit, for the one or more points in time, to a display associated with the aspiration thrombectomy system, data configured to be visually presented on the display, wherein the visually presented data comprises one or more visual indications of whether one or more of the therapeutic-benefit metrics exceeds one or more of the confidence metrics associated with the continuance of the aspiration thrombectomy procedure.