US 12,121,220 B2
Optical systems and methods for intraoperative detection of CSF leaks
Tulio A. Valdez, Palo Alto, CA (US); Mahbuba Tusty, Panorama City, CA (US); David Huland, San Francisco, CA (US); and Oliver Bruns, Neuherberg (DE)
Assigned to The Board of Trustees of the Leland Stanford, Jr. University, Stanford, CA (US)
Filed by THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Stanford, CA (US); and Helmholtz Zentrum Muenchen-Deutsches Forschungszentrum fur Gesundheit und Umwelt (GmbH), Neuherberg (DE)
Filed on Dec. 6, 2021, as Appl. No. 17/543,365.
Application 17/543,365 is a continuation of application No. PCT/US2020/036527, filed on Jun. 7, 2020.
Claims priority of provisional application 62/858,934, filed on Jun. 7, 2019.
Prior Publication US 2022/0087592 A1, Mar. 24, 2022
Int. Cl. A61B 1/06 (2006.01); A61B 1/00 (2006.01); A61B 1/04 (2006.01); A61B 1/233 (2006.01); A61B 5/00 (2006.01)
CPC A61B 1/0638 (2013.01) [A61B 1/00045 (2013.01); A61B 1/043 (2013.01); A61B 1/044 (2022.02); A61B 1/046 (2022.02); A61B 1/063 (2013.01); A61B 1/0684 (2013.01); A61B 1/233 (2013.01); A61B 5/0071 (2013.01); A61B 5/4058 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An apparatus for detecting leakage of cerebrospinal fluid in a subject's body, comprising:
an imaging device comprising a proximal end, a distal end sized for introduction into the body, and an imaging element carried by the distal end;
a light source coupled to the imaging device to simultaneously deliver near infrared (IR) light to excite fluorescent dye administered to the body to cause the dye to fluoresce and deliver short wavelength infrared (SWIR) light;
a camera configured for acquiring images via the imaging element within the SWIR band to facilitate identifying a leak of cerebrospinal fluid; and
a display coupled to the camera to present the images acquired by the camera to facilitate identifying a leak of cerebrospinal fluid based on contrast between the cerebrospinal fluid and the fluorescent dye absorbed by surrounding tissue or blood which is fluorescing within the SWIR band due to absorption of the fluorescent dye.