CPC G16H 20/40 (2018.01) [A61N 5/103 (2013.01); A61N 5/1031 (2013.01); A61N 5/1043 (2013.01); A61N 2005/1087 (2013.01); A61N 2005/1095 (2013.01); A61N 2005/1096 (2013.01)] | 10 Claims |
1. A computer-based method of designing a compensating device for use in ion-based radiotherapy treatment delivery, the device including a substantially disk-shaped structure including on one side of the disk a plurality of elongate elements, the method comprising:
obtaining a model of the compensating device with its properties defined by a set of model parameters, wherein the model parameters include a pixel grid pattern, a thickness of the disk-shaped structure, and widths and lengths of the respective elongate elements,
formulating an optimization problem based on data pertaining to a patient's anatomy, the optimization problem defining planning objectives with respect to dose delivery to a target while sparing other tissues and organs at risk of the patient,
optimizing the values of a set of planning parameters for the compensating device to achieve the planning objectives, the planning parameters including the set of model parameters, wherein the optimization is performed with respect to one or more of variable RBE dose optimization, LET objectives, or beam specific objective functions,
generating a computer-readable file including manufacturing instructions for use by manufacturing equipment for the compensating device, the manufacturing instructions including shape data for manufacturing the plurality of elongate elements of the compensating device, wherein the shape data is determined at least in part based on the optimized values for the set of planning parameters for the compensating device, and
transmitting the computer-readable file to a recipient, to be used by manufacturing equipment when manufacturing the compensating device.
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