US 11,798,179 B2
Structural rectal atlas deformation features for characterizing intra-wall and peri-wall chemoradiation response on magnetic resonance imaging (MRI)
Anant Madabhushi, Shaker Heights, OH (US); Jacob Antunes, Cincinnati, OH (US); Zhouping Wei, Cleveland, OH (US); Pallavi Tiwari, Wexford, PA (US); Satish E. Viswanath, Pepper Pike, OH (US); and Charlems Alvarez Jimenez, Bogotá (CO)
Assigned to Case Western Reserve University, Cleveland, OH (US)
Filed by Case Western Reserve University, Cleveland, OH (US)
Filed on Sep. 22, 2021, as Appl. No. 17/481,625.
Application 17/481,625 is a continuation in part of application No. 16/882,936, filed on May 26, 2020, granted, now 11,158,051.
Claims priority of provisional application 62/879,044, filed on Jul. 26, 2019.
Prior Publication US 2022/0012902 A1, Jan. 13, 2022
Int. Cl. G06K 9/00 (2022.01); G06T 7/33 (2017.01); G06T 7/38 (2017.01); G16H 20/40 (2018.01); G16H 50/70 (2018.01)
CPC G06T 7/33 (2017.01) [G06T 7/38 (2017.01); G16H 20/40 (2018.01); G16H 50/70 (2018.01); G06T 2207/10088 (2013.01); G06T 2207/30096 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, comprising:
accessing an image volume of a rectum comprising a rectal tumor;
generating a forward mapping based on non-rigidly registering a healthy rectal atlas to the image volume;
inverting the forward mapping to generate an inverse mapping from the image volume to the healthy rectal atlas;
determining, based on the inverse mapping, a plurality of deformation vectors associated with a deformation within a rectal wall of the rectum;
computing magnitude based deformation features from the plurality of deformation vectors;
computing orientation based deformation features from the plurality of deformation vectors; and
utilizing one or more of the magnitude based deformation features and one or more of the orientation based deformation features to determine a response of a patient to a chemoradiation treatment.