US 11,795,489 B2
Low cross-linking gelatine
Pierre-Albert Marie Thomas, Son (NL); Claude Françoise Capdepon, Son (NL); Ellen Leona Gabriël Verwee, Son (NL); and Catherine Emmanuelle Thérèse Baron, Son (NL)
Assigned to Rousselot B.V., Son (NL)
Appl. No. 16/319,679
Filed by Rousselot B.V., Son (NL)
PCT Filed Jul. 24, 2017, PCT No. PCT/NL2017/050500
§ 371(c)(1), (2) Date Jan. 22, 2019,
PCT Pub. No. WO2018/016962, PCT Pub. Date Jan. 25, 2018.
Claims priority of application No. 2017219 (NL), filed on Jul. 22, 2016.
Prior Publication US 2020/0377924 A1, Dec. 3, 2020
Int. Cl. C12P 21/06 (2006.01); A61K 9/48 (2006.01)
CPC C12P 21/06 (2013.01) [A61K 9/4825 (2013.01); C12N 2533/54 (2013.01); C12Y 304/21067 (2013.01)] 19 Claims
 
1. A process for the preparation of a gelatine blend comprising the steps of:
a) providing a gelatine extract or a series of gelatine extracts, differing in bloom and viscosity,
b) subjecting a portion of one or more of the gelatine extracts of step a) to an enzymatic treatment to obtain one or more enzymatically treated extracts having a viscosity that is lower than that of the respective extract before said enzymatic treatment, while maintaining the bloom substantially unaffected, the enzymatically treated extracts comprising less than 1.5 w/w % of gelatine-derived peptides having a molecular weight of less than 2000 Da, wherein said enzymatic treatment is carried out using one or more endoproteases,
c) selecting one or more gelatine extracts of step a),
d) combine the selected one or more gelatine extracts of step c) and blend with one or more enzymatically treated extracts of step b) to provide a gelatine composition having a lower viscosity as compared to that of the said combined selected extracts of step c) without being blended with said selected one or more enzymatically treated gelatine extracts of step b), while maintaining the bloom substantially unaffected.