	US 11,795,431 B2
	Ultrathin interfacial layer on a hydrogel to direct its surface properties and cell adhesion
Jeffrey Schwartz, Princeton, NJ (US); Jeffrey Chen, Redmond, WA (US); and Kelly Lim, Princeton, NJ (US)
Assigned to THE TRUSTEES OF PRINCETON UNIVERSITY, Princeton, NJ (US)
Appl. No. 16/639,427
Filed by The Trustees of Princeton University, Princeton, NJ (US)
PCT Filed Aug. 17, 2018, PCT No. PCT/US2018/046879 § 371(c)(1), (2) Date Feb. 14, 2020, PCT Pub. No. WO2019/036594, PCT Pub. Date Feb. 21, 2019.
Claims priority of provisional application 62/546,885, filed on Aug. 17, 2017.
Prior Publication US 2021/0130771 A1, May 6, 2021
Int. Cl. C12N 5/00 (2006.01); A61L 27/38 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); C12N 5/071 (2010.01); C12N 5/0786 (2010.01); C12N 5/077 (2010.01)

CPC C12N 5/0068 (2013.01) [A61L 27/383 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); C12N 5/066 (2013.01); C12N 5/067 (2013.01); C12N 5/069 (2013.01); C12N 5/0629 (2013.01); C12N 5/0645 (2013.01); C12N 5/0654 (2013.01); C12N 5/0655 (2013.01); C12N 5/0656 (2013.01); C12N 5/0657 (2013.01); C12N 5/0658 (2013.01); C12N 5/0661 (2013.01); A61L 2430/32 (2013.01); C12N 2500/20 (2013.01); C12N 2533/30 (2013.01); C12N 2533/74 (2013.01); C12N 2533/78 (2013.01); C12N 2533/90 (2013.01); C12N 2537/10 (2013.01); C12N 2539/00 (2013.01)]

17 Claims

1. A coated hydrogel comprising an inorganic oxide adhesion layer bonded to the surface of an at least partially hydrated, biocompatible, cross-linked hydrophilic polymer hydrogel, wherein said inorganic oxide is selected from the group consisting of the oxides of Ti, Zr, Al, Mg, Si, Zn, Mo, Nb, Ta, Sn, W, and V, and said hydrogel contains at least 10 nmol of water/cm²at the surface or available to the surface of the hydrogel.