US 11,793,877 B2
Controlled drug release from electrospun fibers
Anthony R. D'Amato, Troy, NY (US); Nicholas Schaub, Germantown, MD (US); Andrew Sante Fiumara, Fayetteville, NY (US); Paul Michael Troiano, Housatonic, MA (US); Jesus Cardenas, Lake Forest, CA (US); and Ryan J. Gilbert, Troy, NY (US)
Assigned to Rensselaer Polytechnic Institute, Troy, NY (US)
Appl. No. 15/766,585
Filed by RENSSELAER POLYTECHNIC INSTITUTE, Troy, NY (US)
PCT Filed Oct. 4, 2016, PCT No. PCT/US2016/055314
§ 371(c)(1), (2) Date Apr. 6, 2018,
PCT Pub. No. WO2017/062352, PCT Pub. Date Apr. 13, 2017.
Claims priority of provisional application 62/237,756, filed on Oct. 6, 2015.
Prior Publication US 2018/0289813 A1, Oct. 11, 2018
Int. Cl. A61K 47/34 (2017.01); D04H 1/728 (2012.01); D02J 13/00 (2006.01); D01D 5/00 (2006.01); D01F 6/62 (2006.01); D01F 1/10 (2006.01); A61L 27/18 (2006.01); A61L 27/54 (2006.01); A61K 9/70 (2006.01); A61L 15/44 (2006.01); A61K 31/455 (2006.01); D01F 6/68 (2006.01)
CPC A61K 47/34 (2013.01) [A61K 9/70 (2013.01); A61L 15/44 (2013.01); A61L 27/18 (2013.01); A61L 27/54 (2013.01); D01D 5/003 (2013.01); D01F 1/10 (2013.01); D01F 6/625 (2013.01); D02J 13/00 (2013.01); D02J 13/003 (2013.01); D04H 1/728 (2013.01); A61K 31/455 (2013.01); A61K 2300/00 (2013.01); A61L 2300/434 (2013.01); A61L 2300/602 (2013.01); D01F 6/68 (2013.01)] 5 Claims
 
1. A drug delivery system comprising: a first electrospun poly-L-lactic acid (PLLA) fiber scaffold (EFS) having a first crystallinity percentage; a second PLLA EFS having a second crystallinity percentage different than that of the first PLLA EFS; and at least one active pharmaceutical ingredient (API), wherein the at least one API is released from the first PLLA EFS at a first rate and the at least one API is released from the second PLLA EFS at a second rate different than the first release rate upon administration of the drug delivery system to an individual,
wherein the first PLLA EFS is heat treated at a first temperature and the second PLLA EFS is heat treated at a second temperature, and
wherein the first temperature is between about 50° C. and about 60° C. and the second temperature is at least 80° C.