CPC A61K 39/245 (2013.01) [A61K 9/0036 (2013.01); A61P 31/22 (2018.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/11 (2013.01); A61K 2039/53 (2013.01); A61K 2039/54 (2013.01); A61K 2039/57 (2013.01); C12N 2710/16622 (2013.01)] | 25 Claims |
1. A composition comprising (a) RNA encoding the ectodomain of Herpes Simplex Virus (HSV) glycoprotein D (gD), wherein the ectodomain consists of a sequence that is at least 98% identical to SEQ ID NO: 5, (b) RNA encoding the ectodomain of HSV glycoprotein C (gC), wherein the ectodomain consists of a sequence that is at least 98% identical to SEQ ID NO: 11, and (c) RNA encoding the ectodomain of HSV glycoprotein E (gE), wherein the ectodomain consists of a sequence that is at least 98% identical to SEQ ID NO: 17, wherein one or more of said RNAs is a nucleoside modified RNA.
|