CPC A61K 31/57 (2013.01) [A61K 9/1075 (2013.01); A61K 9/16 (2013.01); A61K 9/48 (2013.01); A61K 9/4825 (2013.01); A61K 9/4858 (2013.01); A61K 9/7023 (2013.01); A61K 31/565 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01)] | 20 Claims |
1. A method of treating a menopause symptom in a woman with a uterus comprising: administering an effective amount of a pharmaceutical composition, the pharmaceutical composition comprising:
a solubilizing agent comprising:
mono- and diglycerides of capric and caprylic acid; and
at least one of lauroyl macrogol-32 glycerides EP, lauroyl polyoxyl-32 glycerides NF, or lauroyl polyoxylglycerides;
progesterone, wherein the progesterone is micronized and partially solubilized; and
estradiol, the estradiol being at least about 90% solubilized in the solubilizing agent;
wherein the estradiol and the progesterone are present in the solubilizing agent, and the micronized progesterone is uniformly dispersed.
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