US 11,793,780 B2
Prodrugs of treprosiinil
Hitesh Batra, Herndon, VA (US); Liang Guo, Vienna, VA (US); Patrick Poisson, Chapel Hill, NC (US); Sri Harsha Tummala, Owings Mills, MD (US); and Elizabeth Ann Harris, Lagrangeville, NY (US)
Assigned to United Therapeutics Corporation, Silver Spring, MD (US); and Mann Kind Corporation, Westlake Village, CA (US)
Filed by United Therapeutics Corporation, Silver Spring, MD (US); and MannKind Corporation, Westlake Village, CA (US)
Filed on Jun. 8, 2021, as Appl. No. 17/342,377.
Claims priority of provisional application 63/036,561, filed on Jun. 9, 2020.
Prior Publication US 2021/0378996 A1, Dec. 9, 2021
Int. Cl. A61K 31/192 (2006.01); A61K 47/54 (2017.01)
CPC A61K 31/192 (2013.01) [A61K 47/545 (2017.08)] 20 Claims
 
1. A compound of formula 5a or 5b:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof,
wherein R5 is H or a polymeric carrier.