CPC A61K 9/127 (2013.01) [A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 31/405 (2013.01); A61K 31/519 (2013.01); A61K 31/573 (2013.01); A61K 38/1793 (2013.01); A61K 47/24 (2013.01); A61K 47/28 (2013.01); C07K 2319/30 (2013.01)] | 21 Claims |
1. A mixture for intraarticular delivery of a therapeutic agent, the mixture comprising:
a first phospholipid, a second phospholipid, and cholesterol, wherein the first phospholipid is selected from the group consisting of 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC), soy phosphatidylcholine (SPC), and egg phosphatidylcholine (EPC), and the second phospholipid is polyethyleneglycol distearoylphosphatidylethanolamine (PEG-DSPE) or dipalmitoylphosphatidylglycerol (DOPG); and
wherein the cholesterol is at a mole percent of about 10 to about 33 based on the total amount of the first phospholipid, the second phospholipid and cholesterol.
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