US 12,452,530 B2
Intelligent sample tilt adjustment with zones having variable size
Lara Zlokapa, San Diego, CA (US); Jeffrey Gau, San Mateo, CA (US); and Matthew Hage, San Diego, CA (US)
Assigned to ILLUMINA, INC., San Diego, CA (US)
Filed by ILLUMINA, INC., San Diego, CA (US)
Filed on Dec. 20, 2023, as Appl. No. 18/391,028.
Prior Publication US 2025/0211849 A1, Jun. 26, 2025
Int. Cl. H04N 23/60 (2023.01); G02B 7/36 (2021.01); G06T 7/70 (2017.01); H04N 23/695 (2023.01)
CPC H04N 23/64 (2023.01) [G02B 7/36 (2013.01); G06T 7/70 (2017.01); H04N 23/695 (2023.01); G06T 2207/30004 (2013.01); G06T 2207/30244 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A non-transitory computer-readable medium having executable instructions stored thereon that, when executed by a processor, causes an imaging system to perform operations comprising:
obtaining surface profile data of a swath of a sample, the swath divided into multiple tiles, and the surface profile data including surface profile data for each tile of the multiple tiles;
calculating, based at least on a threshold residual and the surface profile data of the swath, one or more zones of the swath that include the multiple tiles, each zone of the one or more zones including a respective one or more of the tiles that are adjacent; and
associating, based on the surface profile data associated with the one or more tiles of each zone, a detilt value or a detip value with each zone, the detilt value or the detip value indicating an amount to adjust, before capturing one or more images of the zone, a relative tilt or tip between the sample and an image sensor of the imaging system capturing the one or more images.