US 12,451,215 B2
Method for identifying a candidate, namely a gene location and/or a sequence variant, indicative for at least one (phenotypic) trait
Bjoern Oest Hansen, Leipzig (DE)
Assigned to KWS SAAT SE & Co. KGaA, Einbeck (DE)
Filed by KWS SAAT SE & Co. KGaA, Einbeck (DE)
Filed on Mar. 8, 2024, as Appl. No. 18/600,357.
Claims priority of application No. 102023105888.6 (DE), filed on Mar. 9, 2023.
Prior Publication US 2024/0304278 A1, Sep. 12, 2024
Int. Cl. G16B 20/00 (2019.01); G16B 40/20 (2019.01)
CPC G16B 20/00 (2019.02) [G16B 40/20 (2019.02)] 14 Claims
OG exemplary drawing
 
1. A method for identifying at least one candidate (Loc), namely a gene location and/or a sequence variant, indicative for at least one selected (phenotypic) trait of an organism, in particular of a plant, comprising the steps of:
a. receiving a plurality of candidate lists (Can1, Can2, Can3) of candidates (Loc), the candidate lists being ordered;
b. receiving a reference set (RefDB) with gene locations and/or sequence variants;
c. matching at least a subset of candidates (Loc) from the candidate lists (Can1, Can2, Can3) with the reference list (RefDB) to determine an evaluation value (EV) for at least the subset;
d. assigning each evaluation value (EV) to the respective candidate (Loc) in the respective candidate lists (Can1, Can2, Can3);
e. calculating, for each candidate list, a performance value based on the evaluation value (EV), in particular by using the evaluation values (EV), and calculating a (discounted) cumulative gain for each candidate list (Can1, Can2, Can3 taking into consideration the order of the candidate in the respective list and the evaluation value (EV) assigned to the respective candidate in the respective candidate list (Can1, Can2, Can3); and
f. selecting at least one candidate (Loc) as (preferred) candidate (Loc) from one of the candidate lists (Can1, Can2, Can3) using the performance values.