US 12,449,422 B2
Method and composition matter for immunoproteasome-mediated delivery into living cells
Darci J. Trader, West Lafayette, IN (US); and Breanna Zerfas, Reading, MA (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Appl. No. 17/428,676
Filed by Purdue Research Foundation, West Lafayette, IN (US)
PCT Filed Jan. 29, 2020, PCT No. PCT/US2020/015540
§ 371(c)(1), (2) Date Aug. 5, 2021,
PCT Pub. No. WO2020/163126, PCT Pub. Date Aug. 13, 2020.
Claims priority of provisional application 62/801,640, filed on Feb. 5, 2019.
Prior Publication US 2022/0120756 A1, Apr. 21, 2022
Int. Cl. G01N 33/58 (2006.01); A61K 39/00 (2006.01); C07K 5/11 (2006.01)
CPC G01N 33/582 (2013.01) [A61K 39/0011 (2013.01); C07K 5/1019 (2013.01)] 13 Claims
 
1. A compound for delivering a cargo into a living cell comprising a compound (I)

OG Complex Work Unit Chemistry
or a salt thereof, wherein R1 is said cargo to be delivered to said living cell; wherein said cell is producing immunoproteasomes;
wherein said cargo further comprises a moiety connected thereto that helps penetrate said living cell membrane thereby delivering said cargo;
and wherein said moiety that penetrates said living cell membrane comprises

OG Complex Work Unit Chemistry
or a salt thereof, wherein *- denotes the connection point to the cargo.