US 12,449,365 B2
Raman scattering spectrometric apparatus and Raman scattering spectroscopic method
Koji Sugioka, Wako (JP); and Shi Bai, Wako (JP)
Assigned to RIKEN, Wako (JP)
Appl. No. 18/010,497
Filed by RIKEN, Wako (JP)
PCT Filed Jun. 7, 2021, PCT No. PCT/JP2021/021620
§ 371(c)(1), (2) Date Dec. 15, 2022,
PCT Pub. No. WO2021/256320, PCT Pub. Date Dec. 23, 2021.
Claims priority of application No. 2020-103730 (JP), filed on Jun. 16, 2020.
Prior Publication US 2023/0236129 A1, Jul. 27, 2023
Int. Cl. G01N 21/65 (2006.01); G01J 3/44 (2006.01)
CPC G01N 21/65 (2013.01) [G01J 3/44 (2013.01); G01N 21/658 (2013.01); G01N 2201/06113 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A Raman scattering spectrometric apparatus, comprising:
an irradiation unit configured to emit a laser beam;
a chip having a channel in which a metal nanostructure is formed;
a solution introducing unit configured to introduce an analyte solution into the part of the channel in the chip; and
a measuring unit configured to measure Raman scattering light induced by irradiation with the laser beam;
wherein a measurement is performed by irradiating the laser beam along a liquid-air interface of the analyte solution formed on the metal nanostructure, wherein a direction of the laser beam irradiation is parallel to and along the interface; and
wherein the apparatus further comprises a control unit that acquires an image of the laser-irradiated area and moves a sample stage following a position of the liquid-air interface such that there is a continuous measurement where the liquid-air interface of the analyte solution is positioned at the laser-irradiated area as the interface moves due to evaporation.