US 12,449,361 B2
Multiplex optical stimulus and readout
Gabriel Benito Borja, Boston, MA (US); Yang Lu, Cambridge, MA (US); Benjamin Harwood, Cambridge, MA (US); Hongkang Zhang, Wellesley, MA (US); Christopher Werley, Cambridge, MA (US); Owen McManus, Belmont, MA (US); and Graham T. Dempsey, Sudbury, MA (US)
Assigned to QUIVER HOLDINGS INC., Cambridge, MA (US)
Filed by QUIVER HOLDINGS INC., Cambridge, MA (US)
Filed on May 3, 2024, as Appl. No. 18/654,828.
Application 18/654,828 is a continuation of application No. 17/854,425, filed on Jun. 30, 2022, granted, now 12,105,023.
Claims priority of provisional application 63/217,145, filed on Jun. 30, 2021.
Prior Publication US 2024/0295496 A1, Sep. 5, 2024
Int. Cl. G01N 21/64 (2006.01); B01L 9/00 (2006.01); G01N 21/01 (2006.01)
CPC G01N 21/6428 (2013.01) [B01L 9/523 (2013.01); G01N 21/01 (2013.01); B01L 2200/025 (2013.01); B01L 2300/0654 (2013.01); G01N 2201/02 (2013.01); G01N 2201/0636 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A multi-well plate reader comprising:
a reading platform to receive a multi-well plate;
a plurality of optical channels, each optical channel capable of transmitting light at a plurality of different wavelengths to, and detecting light at a plurality of different wavelengths from, a set of wells of the multi-well plate, wherein each optical channel comprises:
at least three light sources for emitting three beams of light at three distinct wavelengths and to be transmitted to the set of wells; and
one or more dichroic mirrors to join at least two of the beams of light in space and pass the two joined beams of light through at least one homogenizer for spatially homogenizing the two joined beams of light; and
a control system operable to control environmental conditions of a sample in the multi-well plate.