US 12,449,358 B2
Apparatuses and methods for examining the movement of constituents within tissue cells
David D. Nolte, Lafayette, IN (US); Kwan Jeong, Seoul (KR); Maria Josef Lopera, Medellin (CO); and John J. Turek, West Lafayette, IN (US)
Assigned to PURDUE RESEARCH FOUNDATION, West Lafayette, IN (US)
Appl. No. 18/036,360
Filed by PURDUE RESEARCH FOUNDATION, West Lafayette, IN (US)
PCT Filed Nov. 10, 2021, PCT No. PCT/US2021/072340
§ 371(c)(1), (2) Date May 10, 2023,
PCT Pub. No. WO2022/104347, PCT Pub. Date May 19, 2022.
Claims priority of provisional application 63/111,635, filed on Nov. 10, 2020.
Prior Publication US 2024/0011903 A1, Jan. 11, 2024
Int. Cl. A61B 5/00 (2006.01); G01J 3/02 (2006.01); G01J 9/02 (2006.01); G01N 21/47 (2006.01); G01N 15/10 (2006.01)
CPC G01N 21/474 (2013.01) [G01J 3/0208 (2013.01); G01J 3/021 (2013.01); G01J 9/02 (2013.01); G01N 2015/1006 (2013.01)] 28 Claims
OG exemplary drawing
 
1. An apparatus for imaging a target sample, comprising:
a target sample support configured and adapted to support a target sample;
a light source configured and adapted to produce light;
means for diffusely scattering the light produced by the light source off the target sample;
means for producing two crossing beams from the light after the light has been diffusely scattered off the target sample, said means for producing two crossing beams focusing the light at a detection plane; and
an imaging device positioned at the detection plane, the imaging device configured and adapted to create an image from the light received by the imaging device.