	US 12,448,623 B2
	siRNA specifically binding to M2 macrophage CD206 and application thereof
Gang Niu, Beijing (CN); and Huanran Tan, Beijing (CN)
Appl. No. 18/864,911
Filed by Gang Niu, Beijing (CN); and Huanran Tan, Beijing (CN)
PCT Filed Apr. 21, 2023, PCT No. PCT/CN2023/089770 § 371(c)(1), (2) Date Nov. 12, 2024, PCT Pub. No. WO2023/216843, PCT Pub. Date Nov. 16, 2023.
Claims priority of application No. 202210514519.6 (CN), filed on May 12, 2022.
Prior Publication US 2025/0163431 A1, May 22, 2025
Int. Cl. C12N 15/113 (2010.01); A61P 35/00 (2006.01)

CPC C12N 15/1138 (2013.01) [A61P 35/00 (2018.01); C12N 2310/14 (2013.01)]

3 Claims

1. An siRNA specifically targeting M2 macrophage CD206, wherein the siRNA is:

1) One or more of siRNA-1, siRNA-2, siRNA-3, siRNA-4, siRNA-5, and siRNA-6; or,

2) one or more of siRNA-7, siRNA-8, siRNA-9, siRNA-10, siRNA-11, and siRNA-12;

wherein in the siRNA-1, the sense strand nucleotide sequence is shown as SEQ ID NO: 1, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 2;

in the siRNA-2, the sense strand nucleotide sequence is shown as SEQ ID NO: 3, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 4;

in the siRNA-3, the sense strand nucleotide sequence is shown as SEQ ID NO: 5, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 6;

in the siRNA-4, the sense strand nucleotide sequence is shown as SEQ ID NO: 7, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 8;

in the siRNA-5, the sense strand nucleotide sequence is shown as SEQ ID NO: 9, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 10;

in the siRNA-6, the sense strand nucleotide sequence is shown as SEQ ID NO: 11, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 12;

in the siRNA-7, the sense strand nucleotide sequence is shown as SEQ ID NO: 13, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 14 ;

in the siRNA-8, the sense strand nucleotide sequence is shown as SEQ ID NO: 15, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 16 ;

in the siRNA-9, the sense strand nucleotide sequence is shown as SEQ ID NO: 17, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 18;

in the siRNA-10, the sense strand nucleotide sequence is shown as SEQ ID NO: 19, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 20;

in the siRNA-11, the sense strand nucleotide sequence is shown as SEQ ID NO: 21, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 22;

in the siRNA-12, the sense strand nucleotide sequence is shown as SEQ ID NO: 23, and the antisense strand nucleotide sequence is shown as SEQ ID NO: 24.