US 12,448,602 B2
Induced photoreceptor cells and methods for their production
Volker Busskamp, Bonn (DE); Marta Zuzic, Bonn (DE); and Anka Kempe, Dresden (DE)
Assigned to Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn (DE)
Appl. No. 17/435,235
Filed by Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn (DE)
PCT Filed Mar. 2, 2020, PCT No. PCT/EP2020/055401
§ 371(c)(1), (2) Date Aug. 31, 2021,
PCT Pub. No. WO2020/178222, PCT Pub. Date Sep. 10, 2020.
Claims priority of application No. 19160600 (EP), filed on Mar. 4, 2019; and application No. 19170478 (EP), filed on Apr. 23, 2019.
Prior Publication US 2022/0056402 A1, Feb. 24, 2022
Int. Cl. C12N 5/0793 (2010.01); A61K 35/30 (2015.01); A61P 27/02 (2006.01)
CPC C12N 5/062 (2013.01) [A61K 35/30 (2013.01); A61P 27/02 (2018.01)] 18 Claims
OG exemplary drawing
 
1. A method for producing an induced photoreceptor cell from an initial cell, the method comprising providing transcription factors (TFs) comprising GON4L, OTX2, and NEUROD1 to the initial cell, wherein the initial cell is one of a pluripotent or multipotent mammalian cell, a fibroblast, a retinal progenitor cell (RPC), a retinal pigment epithelium (RPE) cell, a Mueller Gilia cell or other cell found in the eye or retina with the proviso that the initial cell is not a photoreceptor cell; and
allowing sufficient time to induce a reprogramming of the initial cell to the induced photoreceptor cell.