US 12,448,498 B2
Hydrogel compositions based on polysaccharides and zwitterionic polymers, and methods for their use
Andrew William Sinclair, Seattle, WA (US); and Timothy James Fujihara, Seattle, WA (US)
Assigned to Taproot Medical Technologies, LLC, Bothell, WA (US)
Filed by Taproot Medical Technologies, LLC, Seattle, WA (US)
Filed on Jun. 10, 2021, as Appl. No. 17/344,106.
Application 17/344,106 is a continuation of application No. PCT/US2019/065630, filed on Dec. 11, 2019.
Claims priority of provisional application 62/782,213, filed on Dec. 19, 2018.
Prior Publication US 2021/0301108 A1, Sep. 30, 2021
Int. Cl. C08L 5/08 (2006.01); A61K 8/04 (2006.01); A61K 8/73 (2006.01); A61K 9/06 (2006.01); A61K 47/36 (2006.01); A61L 27/20 (2006.01); A61L 27/52 (2006.01); C08J 3/075 (2006.01); C12N 5/00 (2006.01)
CPC C08L 5/08 (2013.01) [A61K 8/042 (2013.01); A61K 8/735 (2013.01); A61K 9/06 (2013.01); A61K 47/36 (2013.01); A61L 27/20 (2013.01); A61L 27/52 (2013.01); C08J 3/075 (2013.01); C12N 5/0068 (2013.01); A61L 2430/34 (2013.01); C08J 2305/08 (2013.01); C12N 2533/80 (2013.01)] 31 Claims
OG exemplary drawing
 
1. A hydrogel composition, or a dehydrated composition capable of forming a hydrogel upon hydration, comprising a plurality of polyzwitterionic components (Z*) and polysaccharide components (C*), wherein:
Z* comprises an acrylic or methacrylic backbone having zwitterionic pendant groups;
the polyzwitterionic and polysaccharide components are covalently linked;
one or more of the polysaccharide components (C*) are covalently crosslinked with another polysaccharide component (C*) by acrylate, methacrylate, acrylamide, or methacrylamide modification of the polysaccharide component and subsequent free-radical reaction.