US 12,448,484 B2
Phosphate-containing copolymers for virulence suppression
Carl A. Laskowski, Minneapolis, MN (US); Timothy M. Gillard, St. Paul, MN (US); Ranjani V. Parthasarathy, Woodbury, MN (US); Hannah C. Cohen, St. Paul, MN (US); and Max A. Kruziki, New Brighton, MN (US)
Assigned to 3M Innovative Properties Company, St. Paul, MN (US)
Appl. No. 18/004,910
Filed by 3M INNOVATIVE PROPERTIES COMPANY, St. Paul, MN (US)
PCT Filed Jun. 14, 2021, PCT No. PCT/IB2021/055220
§ 371(c)(1), (2) Date Jan. 10, 2023,
PCT Pub. No. WO2022/013642, PCT Pub. Date Jan. 20, 2022.
Claims priority of provisional application 62/705,806, filed on Jul. 16, 2020.
Prior Publication US 2023/0357500 A1, Nov. 9, 2023
Int. Cl. C08G 65/327 (2006.01); A61K 31/80 (2006.01); A61L 27/34 (2006.01); A61L 27/54 (2006.01); A61L 29/08 (2006.01); A61L 29/16 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01); A61P 31/04 (2006.01); C08G 65/08 (2006.01); C08G 65/22 (2006.01); C08G 65/335 (2006.01); C08G 81/00 (2006.01); C08L 71/02 (2006.01)
CPC C08G 65/327 (2013.01) [A61K 31/80 (2013.01); C08G 65/08 (2013.01); C08G 81/00 (2013.01); C08G 2650/58 (2013.01)] 20 Claims
 
1. A phosphate-containing copolymer comprising a first copolymeric unit comprising:
(a) monomeric units of Formula (I) and

OG Complex Work Unit Chemistry
(b) monomeric units of Formula (II) or a salt thereof and

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(c) optional monomeric units of Formula (III)

OG Complex Work Unit Chemistry
wherein
R1 is hydrogen, alkyl, aryl, alkaryl, or aralkyl;
x is mole percent monomeric units of Formula (I) based on total moles of monomeric units in the first copolymeric unit;
y is mole percent monomeric units of Formula (II) based on total moles of monomeric units in the first copolymeric unit;
z is mole percent monomeric units of Formula (III) based on total moles of monomeric units in the first copolymeric unit;
(x+y+2z) is at least 90 mole percent based on total moles of monomeric units in the first copolymeric unit;
100[(y+2z)÷(x+y+2z)] is in a range of 3.5 to 30 percent; and
each asterisk (*) denotes a connection site to another monomeric unit or to a terminal group.