US 12,448,475 B2
Drug delivery compositions and applications thereof
Alexander Kabanov, Chapel Hill, NC (US); Duhyeong Hwang, Chapel Hill, NC (US); and Marina Sokolsky, Chapel Hill, NC (US)
Assigned to THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, Chapel Hill, NC (US)
Appl. No. 17/620,800
Filed by The University of North Carolina at Chapel Hill, Chapel Hill, NC (US)
PCT Filed Jun. 19, 2020, PCT No. PCT/US2020/038711
§ 371(c)(1), (2) Date Dec. 20, 2021,
PCT Pub. No. WO2020/257635, PCT Pub. Date Dec. 24, 2020.
Claims priority of provisional application 62/864,643, filed on Jun. 21, 2019.
Prior Publication US 2022/0356287 A1, Nov. 10, 2022
Int. Cl. A61K 47/34 (2017.01); A61K 9/107 (2006.01); C08F 20/54 (2006.01); C08F 277/00 (2006.01)
CPC C08F 277/00 (2013.01) [A61K 9/107 (2013.01); A61K 47/34 (2013.01); C08F 20/54 (2013.01)] 20 Claims
 
1. An amphiphilic block copolymer comprising:
a first block and a second block, the second block including oxazoline monomer having a side chain comprising a heteroaryl moiety, wherein the second block is more hydrophobic than the first block, and the heteroaryl moiety is of the formula:

OG Complex Work Unit Chemistry
wherein X, Y and Z are heteroatoms independently selected from the group consisting of N, O, and S, and R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, aryl, heteroaryl, amine, —SH, hydroxyl, halo, carboxyl, and —CONR3 wherein R3 is alkyl and custom character represents a point of attachment of the heteroaryl moiety to the monomer.