US 12,448,454 B2
Humanized anti-CLEC-1A antibodies and antigen-binding fragments thereof
Sabrina Pengam, St Luce S/ Loire (FR); Vanessa Gauttier, Reze (FR); Caroline Mary, Sainte-Pazanne (FR); Nicolas Poirier, Grandchamps des Fontaines (FR); Marion Drouin, Savenay (FR); and Elise Chiffoleau, Nantes (FR)
Assigned to INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris (FR); UNIVERSITE DE NANTES, Nantes (FR); and OSE IMMUNOTHERAPEUTICS, Nantes (FR)
Appl. No. 18/566,391
Filed by OSE IMMUNOTHERAPEUTICS, Nantes (FR); NANTES UNIVERSITE, Nantes (FR); and INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, Paris (FR)
PCT Filed Jun. 8, 2022, PCT No. PCT/EP2022/065600
§ 371(c)(1), (2) Date Dec. 1, 2023,
PCT Pub. No. WO2022/258714, PCT Pub. Date Dec. 15, 2022.
Claims priority of application No. 21305777 (EP), filed on Jun. 8, 2021.
Prior Publication US 2024/0309096 A1, Sep. 19, 2024
Int. Cl. C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/2851 (2013.01) [A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); A61P 35/00 (2018.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/24 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01)] 18 Claims
OG exemplary drawing
 
1. An antibody or antigen-binding fragment thereof that specifically binds to the extracellular domain of human C-type lectin-like receptor-1 member A receptor (CLEC-1A receptor) and which comprises:
an antibody heavy chain variable domain comprising VHCDR1 of SEQ ID NO: 10, VHCDR2 of SEQ ID NO: 11, VHCDR3 of SEQ ID NO: 12; and
an antibody light chain variable domain comprising VLCDR1 of SEQ ID NO: 13, VLCDR2 of SEQ ID NO: 14, VLCDR3 of SEQ ID NO: 15; or
an antibody heavy chain variable domain comprising VHCDR1 of SEQ ID NO: 16, VHCDR2 of SEQ ID NO: 17, VHCDR3 of SEQ ID NO: 18; and
an antibody light chain variable domain comprising VLCDR1 of SEQ ID NO: 19, VLCDR2 of SEQ ID NO:20, VLCDR3 of SEQ ID NO:21; or
an antibody heavy chain variable domain comprising VHCDR1 of SEQ ID NO: 22, VHCDR2 of SEQ ID NO:23, VHCDR3 of SEQ ID NO:24; and
an antibody light chain variable domain comprising VLCDR1 of SEQ ID NO: 25, VLCDR2 of SEQ ID NO:26, VLCDR3 of SEQ ID NO:27.