US 12,448,446 B2
Chimeric antigen receptor and use thereof
Xuanming Yang, Shanghai (CN); Yangxin Fu, Shanghai (CN); and Fanlin Li, Shanghai (CN)
Assigned to SHANGHAI JIAO TONG UNIVERSITY, Shanghai (CN)
Appl. No. 17/426,548
Filed by SHANGHAI JIAO TONG UNIVERSITY, Shanghai (CN)
PCT Filed Jan. 20, 2020, PCT No. PCT/CN2020/073304
§ 371(c)(1), (2) Date Jul. 28, 2021,
PCT Pub. No. WO2020/156335, PCT Pub. Date Aug. 6, 2020.
Claims priority of application No. 201910094658.6 (CN), filed on Jan. 29, 2019.
Prior Publication US 2022/0144948 A1, May 12, 2022
Int. Cl. C07K 16/28 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01)
CPC C07K 16/2809 (2013.01) [A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4202 (2025.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70578 (2013.01); C12N 5/0636 (2013.01); C12N 5/0646 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05); C07K 2317/53 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A chimeric antigen receptor (CAR), comprising:
a transmembrane domain,
a co-stimulatory domain,
an intracellular signaling domain, and
a targeting moiety that comprises an antibody or a fragment thereof and that specifically binds to human and/or mouse T cell receptor (TCR) variable regions Vβ and/or fragments thereof,
wherein said antibody or a fragment comprises heavy chain complementary determining region 1-3 (HCDR1-3) and light chain complementary determining region 1-3 (LCDR1-3) and
the HCDR1 comprises the amino acid sequence of SEQ ID NO:67, the HCDR2 comprises the amino acid sequence of SEQ ID NO:68 and the HCDR3 comprises the amino acid sequence of SEQ ID NO: 69,
the LCDR1 comprises the amino acid sequence in SEQ ID NO:64, the LCDR2 comprises the amino acid sequence in SEQ ID NO:65, and the LCDR3 comprises the amino acid sequence in SEQ ID NO:66.