	US 12,448,436 B2
	Antibody specifically binding to GRP94 or antigen-binding fragment thereof, and uses thereof
Sukmook Lee, Seoul (KR); Ji Woong Kim, Seoul (KR); Yeabin Cho, Gyeonggi-do (KR); and Kyun Heo, Seoul (KR)
Assigned to KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION, Seoul (KR)
Appl. No. 18/009,419
Filed by KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION, Seoul (KR)
PCT Filed Oct. 30, 2020, PCT No. PCT/KR2020/015037 § 371(c)(1), (2) Date Dec. 9, 2022, PCT Pub. No. WO2021/251564, PCT Pub. Date Dec. 16, 2021.
Claims priority of application No. 10-2020-0069859 (KR), filed on Jun. 9, 2020; and application No. 10-2020-0069868 (KR), filed on Jun. 9, 2020.
Prior Publication US 2023/0220056 A1, Jul. 13, 2023
Int. Cl. C07K 16/18 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C12N 15/63 (2006.01)

CPC C07K 16/18 (2013.01) [A61K 39/00 (2013.01); A61P 35/00 (2018.01); C12N 15/63 (2013.01); C07K 2317/565 (2013.01); C07K 2317/92 (2013.01)]

14 Claims

1. An antibody or an antigen-binding fragment thereof, wherein the antibody or the antigen-binding fragment thereof binds specifically to glucose-regulated protein 94 (GRP94) and comprises:

a heavy chain variable region comprising heavy chain CDR1 (HCDR1), HCDR2 and HCDR3;

and a light chain variable region comprising light chain CDR1 (LCDR1), LCDR2 and LCDR3;

wherein the antibody or antigen binding fragment thereof comprises any one of i) to iii):

i) HCDR1, HCDR2, and HCDR3 comprising the amino acid sequences set forth in SEQ ID NOs: 1 to 3, respectively, and LCDR1, LCDR2, and LCDR3 comprising the amino acid sequences set forth in SEQ ID NOs: 4 to 6, respectively;

ii) HCDR1, HCDR2, and HCDR3 comprising the amino acid sequences set forth in SEQ ID NOs: 9 to 11, respectively, and LCDR1, LCDR2, and LCDR3 comprising the amino acid sequences set forth in SEQ ID NOs: 12 to 14, respectively; or

iii) HCDR1, HCDR2, and HCDR3 comprising the amino acid sequences set forth in SEQ ID NOs: 17 to 19, respectively, and LCDR1, LCDR2, and LCDR3 comprising the amino acid sequences set forth in SEQ ID NOs: 20 to 22, respectively.