US 12,448,429 B2
T cell receptors specific to b-cell maturation antigen for treatment of cancer
Jooeun Bae, West Roxbury, MA (US); Nikhil C. Munshi, Needham, MA (US); and Kenneth C. Anderson, Wellesley, MA (US)
Assigned to Dana-Farber Cancer Institute, Inc., Boston, MA (US)
Appl. No. 17/430,938
Filed by Dana-Farber Cancer Institute, Inc., Boston, MA (US)
PCT Filed Mar. 5, 2020, PCT No. PCT/US2020/021273
§ 371(c)(1), (2) Date Aug. 13, 2021,
PCT Pub. No. WO2020/181142, PCT Pub. Date Sep. 10, 2020.
Claims priority of provisional application 62/814,622, filed on Mar. 6, 2019.
Prior Publication US 2022/0118018 A1, Apr. 21, 2022
Int. Cl. A61K 35/17 (2025.01); A61K 39/00 (2006.01); A61K 40/11 (2025.01); A61K 40/32 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01); C12N 5/10 (2006.01); C12N 5/16 (2006.01); C12N 15/63 (2006.01)
CPC C07K 14/7051 (2013.01) [A61K 39/001117 (2018.08); A61K 40/11 (2025.01); A61K 40/32 (2025.01); A61K 40/4215 (2025.01); A61P 35/00 (2018.01); C12N 5/0636 (2013.01); A61K 35/17 (2013.01); A61K 2239/48 (2023.05); C12N 5/16 (2013.01); C12N 15/63 (2013.01)] 11 Claims
 
1. A T cell receptor (TCR) comprising:
(a) a T cell receptor alpha chain (TCA) variable domain which is specific for B-cell maturation antigen (BCMA) and which comprises the amino acid sequence set forth in SEQ ID NO:27 and a T cell receptor beta chain (TCB) variable domain comprising the amino acid sequence set forth in SEQ ID NO: 19;
(b) a TCA variable domain comprising the amino acid sequence set forth in SEQ ID NO: 28 and a TCB variable domain comprising the amino acid sequence set forth in SEQ ID NO:20, or differing by 1 to 10 amino acids;
(c) a TCA variable domain comprising the amino acid sequence set forth in SEQ ID NO: 29 and a TCB variable domain comprising the amino acid sequence set forth in SEQ ID NO:21, or differing by 1 to 10 amino acids;
(d) a TCA variable domain comprising the amino acid sequence set forth in SEQ ID NO: 30 and a TCB variable domain comprising the amino acid sequence set forth in SEQ ID NO:22;
(e) a TCA variable domain comprising the amino acid sequence set forth in SEQ ID NO: 31 and a TCB variable domain comprising the amino acid sequence set forth in SEQ ID NO:23, or differing by 1 to 10 amino acids;
(f) a TCA variable domain comprising the amino acid sequence set forth in SEQ ID NO: 32 and a TCB variable domain comprising the amino acid sequence set forth in SEQ ID NO:24;
(g) a TCA variable domain comprising the amino acid sequence set forth in SEQ ID NO: 33 and a TCB variable domain comprising-the amino acid sequence set forth in SEQ ID NO:25 or;
(h) a TCA variable domain comprising the amino acid sequence set forth in SEQ ID NO: 34 and a TCB variable domain comprising the amino acid sequence set forth in SEQ ID NO:26.