US 12,448,426 B2
Chimeric antigen receptors with MYD88 and CD40 costimulatory domains
Stephen Gottschalk, Memphis, TN (US); Brooke Prinzing, Memphis, TN (US); and Giedre Krenciute, Memphis, TN (US)
Assigned to ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., Memphis, TN (US); and BAYLOR COLLEGE OF MEDICINE, Houston, TX (US)
Appl. No. 17/056,181
Filed by ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., Memphis, TN (US); and BAYLOR COLLEGE OF MEDICINE, Houston, TX (US)
PCT Filed May 17, 2019, PCT No. PCT/US2019/032786
§ 371(c)(1), (2) Date Nov. 17, 2020,
PCT Pub. No. WO2019/222579, PCT Pub. Date Nov. 21, 2019.
Claims priority of provisional application 62/672,819, filed on May 17, 2018.
Prior Publication US 2021/0252058 A1, Aug. 19, 2021
Int. Cl. C07H 21/04 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 15/63 (2006.01)
CPC C07K 14/7051 (2013.01) [A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/421 (2025.01); A61K 40/422 (2025.01); A61K 40/4232 (2025.01); A61P 35/00 (2018.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70575 (2013.01); C07K 14/70578 (2013.01); C07K 14/70596 (2013.01); C07K 16/2866 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C07K 2317/622 (2013.01)] 10 Claims
 
1. A polynucleotide encoding a chimeric antigen receptor (CAR) comprising the amino acid sequence of SEQ ID NO: 1, 26, 50, 52, 54, 56, or 58 or an amino acid sequence that has at least 95% sequence identity to SEQ ID NO: 1, 26, 50, 52, 54, 56, or 58.